Kev Tshawb Fawb Tom Qab Broccoli Seed Extract: Txhua tus neeg yuav khoom yuav tsum paub

Yog tias koj muab cov khoom xyaw rau kev noj haus, koj yuav ntsibbroccoli noob extractntawm ib daim ntawv luv luv ntau dua ib zaug. Nws tseem tshwm sim - hauv cov qauv tshuaj tiv thaiv antioxidant, detox stacks, nootropic blends, thiab cov khoom ua si rov qab. Tab sis pes tsawg tus neeg yuav khoom nkag siab tias vim li cas nws nyob ntawd?

Cov lus teb nyob hauv chemistry. Tshwj xeeb, hauv glucosinolate hu ua glucoraphanin thiab enzyme -tsav cov tshuaj tiv thaiv uas hloov nws mus rau sulforaphane - yog ib qho ntawm feem ntau kawm txog phytonutrients hauv kev noj zaub mov niaj hnub no. Kev nkag siab tias chemistry tsis yog kev kawm xwb. Nws cuam tshuam ncaj qha rau cov ntsiab lus tshwj xeeb uas koj yuav tsum yuav, koj yuav tsum khaws nws li cas, thiab daim ntawv teev npe twg koj tuaj yeem tiv thaiv tau zoo.

Wb taug kev mus.

Glucoraphanin: Tus Thawj Saib Xyuas Kev Ruaj Ntseg Uas Tseem Ceeb

Feem ntau cov neeg hauv kev lag luam ntxiv tham txog sulforaphane. Tsawg tham txog glucoraphanin - thiab qhov ntawd yog qhov yuam kev.

Glucoraphanin yog glucosinolate ua ntej rau sulforaphane. Nws pom muaj nyob hauv Brassica oleracea var. italica - broccoli - nrog rau qhov siab tshaj plaws sau tseg hauv cov noob tsis yog -germinated noob. Kev tshawb fawb luam tawm tau lees paub tias qhov siab tshaj plaws ntawm glucoraphanin hauv cov nroj tsuag broccoli tshwm sim hauv cov noob, ntsuas txog 72.86 ± 10.63 μmol / g tshiab qhov hnyav hauv qee cov cultivars.

Raws li cov nroj tsuag germinates thiab mature, glucoraphanin theem poob sharply. Thaum lub sij hawm koj tab tom saib ntawm broccoli floret paub tab, glucoraphanin concentration yog ib feem ntawm cov noob uas muaj.

Nov yog vim li cas qhov no tseem ceeb rau koj cov qauv:

● Glucoraphanin yog tshuaj ruaj khov. Nws muaj sia nyob extraction, manufacturing, thiab txee cia yam tsis muaj degradation tseem ceeb.

● Sulforaphane yog reactive thiab volatile. Nws degrades nyob rau hauv tshav kub, av noo, thiab ntev cia - ua rau nws tsis zoo neeg sib tw rau standardized ntxiv cov khoom xyaw.

● Kev xa cov glucoraphanin thiab tso cai rau endogenous myrosinase - tam sim no hauv plab microbiota - kom ua tiav cov kev hloov pauv hauv vivo yog lub tswv yim bioavailability zoo dua.

A broccoli noob extractstandardized rau glucoraphanin los ntawm HPLC muab koj cov ntaub ntawv pov thawj, ruaj khov, batch- cov khoom sib xyaw ua ke. Qhov ntawd yog qhov specification tsim nyog muab.

Yuav Ua Li Cas Sulforaphane Forms: Myrosinase Mechanism

Glucoraphanin tsis dhau los ua sulforaphane ntawm nws tus kheej. Nws xav tau myrosinase - ib qho thioglucosidase enzyme - los ua kom cov tshuaj tiv thaiv hydrolysis.

Hauv cov ntaub so ntswg tsis zoo, glucoraphanin thiab myrosinase khaws cia rau hauv cov cellular compartments. Thaum cog cov hlwb raug cuam tshuam - los ntawm kev zom, txiav, lossis ua haujlwm - ob qho tib si los rau hauv kev sib cuag thiab cov tshuaj tiv thaiv pib.

Txoj kev tshuaj tiv thaiv zoo li no:

Glucoraphanin + Myrosinase → Sulforaphane + Glucose + Sulfate

Txawm li cas los xij, muaj qhov nyuaj. Ib qho myrosinase co-factor hu ua epithiospecifier protein (ESP) sib tw nrog sulforaphane tsim. Thaum ESP nquag ua haujlwm - tshwj xeeb tshaj yog nyob rau hauv qis dua - cov tshuaj tiv thaiv hloov mus rau sulforaphane nitrile es tsis txhob, uas muaj kev ua haujlwm lom neeg tsawg.

Qhov no yog vim li cas ua qhov kub thiab txias tseem ceeb heev nyob rau hauv extract manufacturing:

● Kev kho cua sov me me (kwv yees li 60-70 degree) ua rau ESP tsis ua kom puas myrosinase nkaus, ua kom muaj txiaj ntsig zoo ntawm sulforaphane.

● Ntau dhau cua sov ua rau myrosinase tag nrho, ua rau glucoraphanin hloov tsis tau tshwj tsis yog tias plab microbiota muab cov kev ua ub no.

● Tsis muaj kev kho cua sov khaws cia ob qho tib si myrosinase thiab ESP - uas tuaj yeem txo cov txiaj ntsig sulforaphane nyob ntawm cov xwm txheej.

Rau myrosinase - tsis ua haujlwmbroccoli noob extract- feem ntau ntxiv-qib daim ntawv - glucoraphanin raug xa mus zoo, thiab kev hloov pauv yog nyob ntawm tus neeg siv lub plab microbiome. Kev tshawb fawb lees paub txoj hauv kev no ua rau ntsuas tau sulforaphane bioavailability.

Txoj Kev Nrf2: Vim Li Cas Sulforaphane Muaj Kev Tshawb Fawb Tom Qab

Sulforaphane lub luag haujlwm tseem ceeb ntawm kev ua haujlwm yog kev ua haujlwm ntawm Nrf2 - Nuclear factor erythroid 2-related factor 2. Nrf2 functions as a transcription factor and master regulator of the body's cytoprotective gene expression.

Raws li cov xwm txheej hauv paus, Nrf2 tau tuav tsis muaj zog hauv cytoplasm los ntawm cov protein hu ua Keap1. Sulforaphane hloov kho cov cysteine ​​residues ntawm Keap1, tso Nrf2 los hloov mus rau lub nucleus. Thaum nyob ntawd, nws khi rau cov ntsiab lus teb antioxidant (AREs) thiab txhawb nqa lub cascade ntawm Phase II detoxification thiab antioxidant enzymes, suav nrog:

● NQO1 (NAD(P)H quinone oxidoreductase 1)

● HO-1 (Heme oxygenase-1)

● Glutathione S-transferases (GSTs)

● Thioredoxin reductase

● Ferritin

Cov txheej txheem no tau piav qhia raws li kev tiv thaiv tsis ncaj ncees - es tsis yog tshem tawm cov dawb radicals ncaj qha, sulforaphane ua kom lub cev muaj peev xwm ua kom muaj zog antioxidant. Cov nyhuv downstream yog dav thiab ruaj khov dua li cov tshuaj tiv thaiv kab mob ncaj qha xws li vitamin C lossis vitamin E.

Txoj hauv kev Nrf2 tau tshawb xyuas kev kho mob thoob plaws ntau yam kev noj qab haus huv:

● Kev txhawb nqa lub siab thiab kev tshem tawm cov tshuaj lom - Phase II enzyme induction yog ncaj qha cuam tshuam rau kev tshem tawm cov kab mob hepatic xenobiotic.

● Neuroinflammation - Nrf2 activation tau kawm nyob rau hauv cov ntsiab lus ntawm oxidative kev nyuaj siab nyob rau hauv cov ntaub so ntswg neural

● Kab mob plawv - HO-1 induction tau sau tseg cov teebmeem vasoprotective

● Metabolic noj qab haus huv - Sulforaphane tau raug tshuaj xyuas rau nws cov teebmeem ntawm insulin rhiab heev thiab glycemic cim

Qhov dav ntawm kev siv tshuab no piav qhia yog vim li cas broccoli noob extract tseem tshwm sim nyob rau ntau pawg ntxiv.

Daim ntawv qhia tshwj xeeb yuav tsum qhia rau koj li cas

Ntawm no yog qhov uas qhov kev sib tham txog kev yuav khoom tau txais txiaj ntsig. Tsis yog txhuabroccoli noob extractntawm kev ua lag luam yog sib npaug - thiab qhov sib txawv tseem ceeb.

Glucoraphanin feem pua ​​​​thiab txoj kev kuaj mob

Kev lag luam tus qauv ntsuas rau ntxiv- cov khoom qib siab dua lossis sib npaug li 10% glucoraphanin los ntawm HPLC. Qee tus neeg muag khoom hais txog tag nrho cov ntsiab lus ntawm glucosinolate los ntawm UV spectrophotometric - ib txoj hauv kev tsawg dua uas tuaj yeem overstate glucoraphanin cov ntsiab lus los ntawm kev ntes lwm yam glucosinolates. Ib txwm nug: dab tsi compound, hom twg, dab tsi siv tus qauv?

Myrosinase xwm txheej

● Myrosinase-inactivated - Glucoraphanin ruaj khov; kev hloov pauv tshwm sim hauv plab. Qhov zoo tshaj plaws rau feem ntau cov ntawv thov ntxiv.

● Myrosinase- nquag - Kev hloov pauv pib tam sim ntawd thaum muaj dej. Yuav tsum tau ceev faj tuav thiab txias -chaw cia kom tiv thaiv kom tsis txhob ntxov ntxov sulforaphane degradation.

Epithiospecifier protein (ESP) xwm txheej

Kev ua ESP hloov pauv glucoraphanin hydrolysis mus rau sulforaphane nitrile es tsis yog sulforaphane. Ib tus neeg muag khoom zoo yuav tsum muaj peev xwm paub meej tias lawv cov txheej txheem rho tawm los ntawm ESP inactivation.

Hnyav hlau thiab tshuaj tua kab residue

Cov qoob loo Brassica paub tias cov khoom hnyav hlau los ntawm av. Batch-ICP tshwj xeeb-MS cov ntaub ntawv rau Pb, As, Hg, thiab Cd tsis yog- sib tham. Ntau-Kev tshuaj ntsuam xyuas tshuaj tua kab (GC-MS/LC-MS/MS, 200+} vaj huam sib luag)) yog qhov tseem ceeb sib npaug - tshwj xeeb tshaj yog rau EU- cov khoom tsim nyog raws li Txoj Cai (EC) No 396/2005.

Batch-rau-batch sib xws

Thov COAs los ntawm peb lossis ntau qhov kev tsim khoom sib law liag. Glucoraphanin variance ntau dua ± 1.0% hla cov khoom lag luam qhia tias kev tswj tsis txaus lossis kev sib xyaw ua ke.

Broccoli Noob Extractvs. Broccoli Sprout Powder: Kev lag luam ruaj khov-Tawm

Qhov kev sib piv no tshwm sim tas li nyob rau hauv kev sib tham txog kev sib tham - thiab cov lus teb yog ntau nuanced tshaj li feem ntau cov khoom catalogs qhia.

Cov kev lag luam tseem ceeb-tawm: sprout hmoov muaj cov nquag myrosinase, uas zoo li qhov zoo dua. Hauv kev xyaum, active myrosinase txhais tau hais tias sulforaphane hloov dua siab tshiab pib thaum lub sij hawm ua thiab cia - ua ntej cov khoom mus txog rau cov neeg siv khoom. Thaum lub sij hawm sprout-raws li cov khoom noj, ib feem ntawm sulforaphane tej zaum yuav tau degraded.

Noob Extract nrog inactivated myrosinase muab glucoraphanin zoo rau lub plab, qhov twg microbial myrosinase ua tiav kev hloov pauv. Cov ntaub ntawv luam tawm bioavailability paub meej tias txoj kev no ua rau ntsuas qhov systemic sulforaphane.

Yuav ua li cas Jiuyuan Biotech Sources thiab Manufactures Broccoli Seed Extract

Ntawm Jiuyuan Biotech, peb muab cov kws kho mob -qib broccoli noob extract standardized rau ntau dua los yog sib npaug rau 10% glucoraphanin los ntawm HPLC. Peb qhov chaw tsim khoom yog nyob hauv Shaanxi, Tuam Tshoj - thaj chaw cog qoob loo tseem ceeb rau Brassica oleracea var. italica.

Dab tsi peb cov neeg siv khoom muaj nqis tsis tu ncua:

● Nyob rau hauv -lub tsev HPLC standardization - Txhua batch tau soj ntsuam tiv thaiv ib tug certified glucoraphanin tus qauv siv ua ntej tso

● Myrosinase-inactivated processing - Ua kom muaj kev ruaj ntseg ntawm glucoraphanin los ntawm cov saw hlau.

● ESP- hais txog kev rho tawm raws tu qauv - Txo qhov tsim ntawm nitrile thiab ua kom muaj zog sulforaphane yield

● Tag nrho traceability - Los ntawm kev cog lus cog qoob loo los ntawm kev rho tawm, ziab, thiab COA zaum kawg

● Cov ntawv pov thawj - ISO 9001: 2015, FSSC 22000, cGMP, FDA chaw tso npe, Halal, Kosher

● Cov ntaub ntawv tswj hwm kev txhawb nqa - Cov ntaub ntawv qhia txuj ci rau Asmeskas (DSHEA / 21 CFR Part 111), EU cov khoom noj ntxiv, thiab lwm yam kev lag luam tswj hwm

Peb ua haujlwm nrog cov khoom lag luam ntxiv, cov tuam txhab cog lus, thiab cov neeg tsim daim ntawv lo ntiag tug uas xav tau cov ntaub ntawv sib xws, cov ntaub ntawv, kev qhia tshwj xeeb - cov ntaub ntawv ua raws - thiab kev txhawb nqa los siv kom raug.

Qhov Kev Txiav Txim Muag Khoom Simplified

Science qabbroccoli noob extractyog qhov yuam kev tiag tiag - tab sis tsuas yog tias cov khoom xyaw uas koj qhov chaw muab xa tawm raws li daim ntawv thov. Glucoraphanin concentration, myrosinase raws li txoj cai, ESP kev ua, thiab batch-rau-batch sib xws tsis yog cov ntsiab lus thib ob. Lawv txiav txim siab seb koj cov khoom tiav ua tiav.

Cov noob yog qhov feem ntau glucoraphanin- tuab theem ntawm cov nroj tsuag broccoli lub neej voj voog. Ib lub qhov dej-tsim, HPLC-txheej txheem extract captures qhov ceev nyob rau hauv ib tug ruaj khov, formulation- npaj daim ntawv. Qhov ntawd yog cov khoom tsim nyog tsim koj cov khoom nyob ib puag ncig.

Npaj los ntsuam xyuas broccoli noob extract rau koj cov formulation tom ntej? Hu rau pab pawg muaj khoom ntawm Jiuyuan Biotech - peb muab cov qauv, cGMP- tau ntawv pov thawjbroccoli noob extractnrog tag nrho cov ntaub ntawv txhawb nqa rau kev tswj hwm kev lag luam thoob ntiaj teb.

Tiv tauj peb ntawminfo@jiuybiotech.com- peb teb tsis pub dhau ib hnub ua haujlwm.

Cov khoom specifications thiab COA thov:ntawm jiuyuanbio.com

Cov ntaub ntawv

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2. Fahey JW, Wehage SL, Holtzclaw WD, et al. Kev tiv thaiv tib neeg los ntawm cov nroj tsuag glucosinolates: Kev ua tau zoo ntawm kev hloov pauv ntawm glucosinolates rau isothiocyanates los ntawm txoj hnyuv microflora. Kev Tshawb Fawb Kev Tiv Thaiv Kab Mob . 2012; 5(4): 603–611.

3.Guo L, Yang R, Wang Z, Guo Q, Gu Z. Glucoraphanin, sulforaphane thiab myrosinase kev ua haujlwm hauv germinating broccoli sprouts raws li cuam tshuam los ntawm kev loj hlob kub thiab cog cov kab mob. Phau ntawv Journal of Functional Foods. 2014; 9:70–77.

4. Houghton CA, Fassett RG, Coombes JS. Sulforaphane thiab lwm yam nutrigenomic Nrf2 activators: Puas yog tus kws kho mob qhov kev cia siab tuaj yeem sib phim los ntawm qhov tseeb? Oxidative Medicine thiab Cellular Longevity. 2016;2016:7857186.

5.Vanduchova A, Anzenbacher P, Anzenbacherova E. Isothiocyanate los ntawm broccoli, sulforaphane, thiab nws cov khoom. Phau ntawv Journal of Medicinal Food. 2019;22(2):121–126.

6.Shapiro TA, Fahey JW, Dinkova-Kostova AT, et al. Kev nyab xeeb, kev ua siab ntev, thiab cov metabolism hauv broccoli sprout glucosinolates thiab isothiocyanates: Ib theem kuv kawm. Khoom noj khoom haus thiab mob qog noj ntshav. 2006;55(1:53–62.